"Evolutionary Topology Optimization of Continuum Structures" treads new ground with a comprehensive study on the techniques and applications of evolutionary structural optimization (ESO) and its later version bi-directional ESO (BESO) methods. Since the ESO method was first introduced by Xie and Steven in 1992 and the publication of their well-known book "Evolutionary Structural Optimization" in 1997, there have been significant improvements in the techniques as well as important practical applications. The authors present these developments, illustrated by numerous interesting and detailed examples. They clearly demonstrate that the evolutionary structural optimization method is an effective approach capable of solving a wide range of topology optimization problems, including structures with geometrical and material nonlinearities, energy absorbing devices, periodical structures, bridges and buildings.Presents latest developments and applications in this increasingly popular & maturing optimization approach for engineers and architects; Authored by leading researchers in the field who have been working in the area of ESO and BESO developments since their conception; Includes a number of test problems for students as well as a chapter of case studies that includes several recent practical projects in which the authors have been involved; Accompanied by a website housing ESO/BESO computer programs at http: //www.wiley.com/go/huang and test examples, as well as a chapter within the book giving a description and step-by-step instruction on how to use the software package BESO2D.

"Evolutionary Topology Optimization of Continuum Structures" will appeal to researchers and graduate students working in structural design and optimization, and will also be of interest to civil and structural engineers, architects and mechanical engineers involved in creating innovative and efficient structures.

CONTEMPORARY ACCOUNTS IN DRUG DISCOVERY AND DEVELOPMENT A useful guide for medicinal chemists and pharmaceutical scientists Drug discovery is a lengthy and complex process that typically involves identifying an unmet medical need, determining a biological target, chemical library screening to identify a lead, chemical optimization, preclinical studies and clinical trials. This process often takes many years to complete, and relies on practitioners' knowledge of chemistry and biology, but also--and perhaps more importantly--on experience. Improving the success rate in discovery and development through a thorough knowledge of drug discovery principles and advances in technology is critical for advancement in the field. Contemporary Accounts in Drug Discovery and Development provides drug discovery scientists with the knowledge they need to quickly gain mastery of the drug discovery process. A thorough accounting is given for each drug covered within the book, as the authors provide pharmacology, drug metabolism, biology, drug development, and clinical studies for every case, with modern drug discovery principles and technologies incorporated throughout. Contemporary Accounts in Drug Discovery and Development readers will also find Case histories used as an engaging way of learning about the drug discovery/development process Detailed biological rational and background information, drug design principles, SAR development, ADMET considerations, and clinical studies The full history of individual marketed small molecule drugs Coverage of drug candidates that have passed Phase I clinical trials with different modalities, such as antibody drug conjugates (ADC), proteolysis-targeting chimera (PROTAC), and peptide drugs The application of new technologies in drug discovery such as DNA-encoded libraries (DEL), positron emission tomography (PET), and physics-based computational modeling employing free energy perturbation (FEP) Contemporary Accounts in Drug Discovery and Development is a helpful tool for medicinal chemists, organic chemists, pharmacologists, and other scientists in drug research and process development. It may be considered essential reading for graduate courses in drug discovery, medicinal chemistry, drug synthesis, pharmaceutical science, and pharmacology. It is also a useful resource for pharmaceutical industry labs, as well as for libraries.

The impressive, and recent, economic development of Japan and China, has led many to seek understanding beyond the theories of the developmental state, varieties of capitalism, and the world economic system. Leading global scholars on Japan and China provide a comparative analysis of the patterns of modern economic development, their political economy, and the historical and global context of their economic development. Japanese and Chinese experiences of modern economic development are larger than individual theories can make sense of. The experiences of China and Japan point to the fundamental challenge nations have faced in organizing economic and political activities under modern conditions.

The contributors provide a comparative analysis of the modern economic development of Japan and China that are often explained in frameworks of East Asian developmentalism, varies of capitalism or world economic system, and explore their broader significances for the rise and global expansion of modern economy.

This book provides comprehensive coverage on the key issues of Chinese investment in the Australian minerals industry. It offers unique insights into the entry process, the management of Chinese investments, and their success factors and lessons learnt as being impacted upon by the entangling of political, economic, social and competitive forces.

This book provides comprehensive coverage on the key issues of Chinese investment in the Australian minerals industry. It offers unique insights into the entry process, the management of Chinese investments, and their success factors and lessons learnt as being impacted upon by the entangling of political, economic, social and competitive forces.

Learn why some drug discovery and development efforts succeed . . . and others fail

Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and failed drug discovery and development efforts, enabling medicinal chemists and pharmaceutical scientists to learn from actual examples. Each case study focuses on a particular drug and therapeutic target, guiding readers through the drug discovery and development process, including drug design rationale, structure-activity relationships, pharmacology, drug metabolism, biology, and clinical studies.

"Case Studies in Modern Drug Discovery and Development" begins with an introductory chapter that puts into perspective the underlying issues facing the pharmaceutical industry and provides insight into future research opportunities. Next, there are fourteen detailed case studies, examining:

All phases of drug discovery and development from initial idea to commercialization

Some of today's most important and life-saving medications

Drugs designed for different therapeutic areas such as cardiovascular disease, infection, inflammation, cancer, metabolic syndrome, and allergies

Examples of prodrugs and inhaled drugs

Reasons why certain drugs failed to advance to market despite major research investments

Each chapter ends with a list of references leading to the primary literature. There are also plenty of tables and illustrations to help readers fully understand key concepts, processes, and technologies.

Improving the success rate of the drug discovery and development process is paramount to the pharmaceutical industry. With this book as their guide, readers can learn from both successful and unsuccessful efforts in order to apply tested and proven science and technologies that increase the probability of success for new drug discovery and development projects.

Explore the diverse electrical engineering application of polymer composite materials with this in-depth collection edited by leaders in the field Polymer Composites for Electrical Engineering delivers a comprehensive exploration of the fundamental principles, state-of-the-art research, and future challenges of polymer composites. Written from the perspective of electrical engineering applications, like electrical and thermal energy storage, high temperature applications, fire retardance, power cables, electric stress control, and others, the book covers all major application branches of these widely used materials. Rather than focus on polymer composite materials themselves, the distinguished editors have chosen to collect contributions from industry leaders in the area of real and practical electrical engineering applications of polymer composites. The book s relevance will only increase as advanced polymer composites receive more attention and interest in the area of advanced electronic devices and electric power equipment. Unique amongst its peers, Polymer Composites for Electrical Engineering offers readers a collection of practical and insightful materials that will be of great interest to both academic and industrial audiences. Those resources include: A comprehensive discussion of glass fiber reinforced polymer composites for power equipment, including GIS, bushing, transformers, and more) Explorations of polymer composites for capacitors, outdoor insulation, electric stress control, power cable insulation, electrical and thermal energy storage, and high temperature applications A treatment of semi-conductive polymer composites for power cables In-depth analysis of fire-retardant polymer composites for electrical engineering An examination of polymer composite conductors Perfect for postgraduate students and researchers working in the fields of electrical, electronic, and polymer engineering, Polymer Composites for Electrical Engineering will also earn a place in the libraries of those working in the areas of composite materials, energy science and technology, and nanotechnology.

This book constitutes the refereed proceedings of the Second MICCAI Workshop on Data Augmentation, Labelling, and Imperfections, DALI 2022, held in conjunction with MICCAI 2022, in Singapore in September 2022.DALI 2022 accepted 12 papers from the 22 submissions that were reviewed. The papers focus on rigorous study of medical data related to machine learning systems.